Studies on Human Gastric Intrinsic Factor

Studies on Secretion of Gastric Intrinsic Factor in Man.

Studies on antibody to intrinsic factor.

Sera from a group of 79 patients with pernicious anemia were studied for the presence of antibody to intrinsic factor. Two general types of antibody activity were found, and it was possible to distinguish three groups of pernicious anemia sera on the basis of their content of these types. Type I antibody blocks the binding of radioactive vitamin B(12) to intrinsic factor when added to intrinsic...

Nuclear factor-κB1 expression levels in human gastric adenocarcinoma

NF-κB pathway is a link between inflammation and cancer and is involved in cellular responses to different stimuli. Gastrointestinal lumen is exposed to many inflammatory agents such as foods, free radicals and bacterial or viral antigens. The aim of the present study was to evaluate the possible role of NF-κB1in gastric adenocarcinoma. To detect the relative level of NF-κB1transcript, total RN...

Stimulation of Gastric Intrinsic Factor Secretion.

It is uncertain whether the abnormal findings indicate impaired liver function. It has been suggested that they may be a result of the pseudopregnancy state (Tyler, 1964). , While the B.S.P.-removal mechanisms have been found to be impaired in normal pregnancy (Combes et al., 1963), the serum-transaminase levels and the standard B.S.P. retention are not abnormal (Christhilf et al., 1950 ; Combe...

Intrinsic factor secretion in gastric atrophy.

EDITORIAL SYNOPSIS The appearance of the gastric biopsy histologically has been correlated with assay of the intrinsic factor and acid content of the gastric juice, and also with vitamin B12 absorption studies. The loss of intrinsic factor parallels the loss of gastric secretory cells. The assay of intrinsic factor proved a better index of secretory capacity of the mucosa than either acid produ...